Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
Patent 4668685 Issued on May 26, 1987. Estimated Expiration Date: 
May 14, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 14, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3254088 3332950 3393197 N-alkyl-14-hydroxymorphinans and derivatives Patent #: 4161597 InventorApplicationNo. 06/733464 filed on 05/14/1985US Classes:514/279, Polycyclo ring system having the six-membered hetero ring as one of the cyclos514/282, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)514/289, Two of the cyclos share at least three ring members (i.e., bridged) (e.g., morphinans, etc.)546/39, Two of the cyclos share at least three ring members (e.g., etheno morphides, etc.)546/44, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)546/45, Nitrogen or divalent chalcogen double bonded directly to carbocyclic ring of the pentacyclo ring system (e.g., morphinones, etc.)546/46, A single chalcogen is bonded directly to ring carbon of the pentacyclo ring system (e.g., desoxy morphine, etc.)546/63, Two of the cyclos share at least three ring member (i.e., bridged)546/74Two of the cyclos share at least three ring members (e.g., morphinans, etc.)ExaminersPrimary: Daus, Donald G.Assistant: Rivers, Diana G. International ClassesC07D 221/28 (20060101)C07D 221/00 (20060101) C07D 489/02 (20060101) C07D 489/00 (20060101) C07D 489/08 (20060101) AbstractSubstituted benzoate ester prodrug derivatives of 3-hydroxymorphinans are useful as analgesics or narcotic antagonists and provide enhanced bioavailability of 3-hydroxymorphinans from orally administered doses.Other References
Field of SearchOne of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)Nitrogen or divalent chalcogen double bonded directly to carbocyclic ring of the pentacyclo ring system (e.g., morphinones, etc.) A single chalcogen is bonded directly to ring carbon of the pentacyclo ring system (e.g., desoxy morphine, etc.) Two of the cyclos share at least three ring members (e.g., morphinans, etc.) Two of the cyclos share at least three ring member (i.e., bridged) |
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