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US Patent 4666908 - 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use

US Patent Issued on May 19, 1987
Estimated Patent Expiration Date: Icon_subject April 5, 2005Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention relates to novel 5-substituted pyrazolo[4,3-d]pyrimidine-7-one compounds, and compositions, methods of use and processes to make therefor. The novel compounds are useful in the treatment of cardiovascular disorders, such as heart failure or cardiac insufficiency. The novel compounds bind adenosine receptors and selectively inhibit phosphodiesterase.

Other References

  • Synthesis, p. 727 (1981)
  • Bull. Chem. Soc. Japan, 52 (1), 208 (1979)

Inventor

Application

No. 06/720437 filed on 04/05/1985

US Classes:

514/234.2, Three or more ring hetero atoms in the bicyclo ring system514/232.5, Polycyclo ring system having the additional hetero ring as one of the cyclos514/262.1, Exactly four ring nitrogens in the bicyclo ring system544/118, Four or more ring nitrogens in the bicyclo ring system544/262The other cyclo in the bicyclo ring system is five-membered

Field of Search

544/262The other cyclo in the bicyclo ring system is five-membered

Examiners

Primary: Rosen, Sam
Assistant: Benson, Robert

Attorney, Agent or Firm

US Patent References

3165520, 39391611,3-Dimethyl- 1H-pyrazolo(4,3-D) pyrimidine-7 (6H)-ones
Issued on: 02/17/1976
Inventor: Ratajczyk ,   et al.

International Classes

C07D 487/00 (20060101)
C07D 487/04 (20060101)

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