U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use

Patent 4666908 Issued on May 19, 1987. Estimated Expiration Date: Icon_subject April 5, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3165520

1,3-Dimethyl- 1H-pyrazolo(4,3-D) pyrimidine-7 (6H)-ones Patent #: 3939161
Issued on: 02/17/1976
Inventor: Ratajczyk ,   et al.

Inventor

Application

No. 06/720437 filed on 04/05/1985

US Classes:

514/234.2, Three or more ring hetero atoms in the bicyclo ring system514/232.5, Polycyclo ring system having the additional hetero ring as one of the cyclos514/262.1, Exactly four ring nitrogens in the bicyclo ring system544/118, Four or more ring nitrogens in the bicyclo ring system544/262The other cyclo in the bicyclo ring system is five-membered

Examiners

Primary: Rosen, Sam
Assistant: Benson, Robert

Attorney, Agent or Firm

International Classes

C07D 487/00 (20060101)
C07D 487/04 (20060101)

Abstract

The present invention relates to novel 5-substituted pyrazolo[4,3-d]pyrimidine-7-one compounds, and compositions, methods of use and processes to make therefor. The novel compounds are useful in the treatment of cardiovascular disorders, such as heart failure or cardiac insufficiency. The novel compounds bind adenosine receptors and selectively inhibit phosphodiesterase.

Other References

  • Synthesis, p. 727 (1981)
  • Bull. Chem. Soc. Japan, 52 (1), 208 (1979)
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