U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Novel use of benzodiazepine antagonist

Patent 4666903 Issued on May 19, 1987. Estimated Expiration Date: Icon_subject August 13, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventor

Application

No. 06/765257 filed on 08/13/1985

US Classes:

514/220Tricyclo ring system having the seven-membered hetero ring as one of the cyclos

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Class

A61K 31/55 (20060101)

Abstract

Benzodiazepine antagonists are used to regenerate the sensitivity response to and prevent tolerance of benzodiazepine which otherwise develops during chronic benzodiazepine exposure. The administration of a plurality of time spaced doses of the antagonist also prevents benzodiazepine withdrawal symptoms. The preferred benzodiazepine antagonist is flumazepil.

Other References

  • Chem. Abst. 97-138502(Z), 104,176(F) & 174930(W), (1982)
  • Sandra E. File, "Recovery from Lorazepam Tolerance and the Effects of a Benzodiazepine Antagonist (RO 15-1788) on the Development of Tolerance," Psychopharmacology (1982) 77:284-288
  • Scott E. Lukas, Roland R. Griffiths, "Precipitated Withdrawal by a Benzodiazepine Receptor Antagonist (RO 15-1788) After 7 Days of Diazepam", Science, vol. 217, 17 Sep. 1982
  • L. F. McNicholas and W. R. Martin, "The Effect of a Benzodiazepine Antagonist, RO15-1788, In Diazepam Dependent Rats," Life Sciences, vol. 31, pp. 731-737
  • R. J. Lamb and R. R. Griffiths, "Effects of Repeated Ro 15-1788 Administration in Benzodiazepine-Dependent Baboons", European Journal of Pharmacology, vol. 110, No. 2, pp. 257-261
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