Test for Huntington's disease

Patent 4666828 Issued on May 19, 1987. Estimated Expiration Date:

August 15, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventor

Gusella, James F.

Assignee

The General Hospital Corporation

Application

No. 06/640808 filed on 08/15/1984

US Classes:

435/6, Involving nucleic acid435/91.53, Involving a hydrolase (3.)436/811TEST FOR NAMED DISEASE, BODY CONDITION OR ORGAN FUNCTION

Examiners

Primary: Kepplinger, Esther M.
Assistant: Jay, Jeremy M.

Attorney, Agent or Firm

Saidman, Sterne, Kessler & Goldstein

International Class

C12Q 1/68 (20060101)

Abstract

A method for detecting the presence of the gene for Huntington's disease in a subject which comprises analyzing the human chromosome 4 of the subject for a DNA polymorphism, preferably a restriction fragment length polymorphism (RFLP), linked to Huntington's Disease.

Other References

Gusella, J. F. et al. Nature vol. 306, Nov. 17, 1983 pp. 234-238
Botstein, D. et al. Am. J. Hum. Genet. vol. 32, 1980 pp. 314-331
Housman, D. et al. In: Molecular Genetic Neuroscience, (Schmitt, F. O. et al., editors), Raven Press, NY, 1982, p. 415-422
Housman, D. et al. In: Genetic Research Strategies For Psychobiology And Psychiatry, (Gershon, E. S. et al., editors), Boxwood Press, CA., 1981, pp. 17-24
Gusella, J., et al., Banbury Report 14: Recombinant DNA Applications To Human Disease, 261-265 (Sep. 1983)
Gusella et al., Banbury Report 14: Recombinant DNA Applications to Human Disease, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 261-265 (1983)
Gusella et al., Cytogenetics and Cell Genetics, 37 (1-4): 484-485 (1984)