U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Synthesis and purification of d-propoxyphene hydrochloride

Patent 4661625 Issued on April 28, 1987. Estimated Expiration Date: Icon_subject December 2, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventor

Assignee

Application

No. 06/803321 filed on 12/02/1985

US Classes:

560/250Nitrogen in alcohol moiety other than as nitro, nitroso or isocyanate

Examiners

Primary: Lone, Werren B.

Attorney, Agent or Firm

International Classes

C07C 67/03 (20060101)
C07C 67/00 (20060101)

Abstract

New and improved synthesis of ଱-d-propoxyphene hydrochloride by acid chloride reaction between propionyl chloride and ଱-d-1,2-diphenyl-3-methyl-4-dimethylamino-2-butanol (d-oxyphene) with small amounts of thionyl chloride improves yield and substantially simplifies purification.

Other References

  • Pohland et al., "J. Amer. Chem. Soc." vol. 75, (1953), pp. 4458-4461
  • Pohland et al., "J. Amer. Chem. Soc." vol. 77, (1953), pp. 3400-3401
  • Pohland, et al., "J. Organic Chem." vol. 28, (1963), pp. 2483-2484
  • Noller, "Chemistry of Organic Compounds" (1965), pub. W. R. Saunders Co. Phila., p. 711
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