Synthesis and purification of d-propoxyphene hydrochloride
Patent 4661625 Issued on April 28, 1987. Estimated Expiration Date: December 2, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
New and improved synthesis of -d-propoxyphene hydrochloride by acid chloride reaction between propionyl chloride and -d-1,2-diphenyl-3-methyl-4-dimethylamino-2-butanol (d-oxyphene) with small amounts of thionyl chloride improves yield and substantially simplifies purification.
Other References
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