U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Operator-interactive automated chromosome analysis system producing a karyotype

Patent 4656594 Issued on April 7, 1987. Estimated Expiration Date: Icon_subject May 6, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3833796

3883852

3908078

Device for counting and calculating
Patent #: 4054782
Issued on: 10/18/1977
Inventor: Weibel

Method and device for isolating figures in an image
Patent #: 4075658
Issued on: 02/21/1978
Inventor: de Cosnac ,   et al.

Automated clinical system for chromosome analysis
Patent #: 4122518
Issued on: 10/24/1978
Inventor: Castleman ,   et al.

Method and apparatus for automated classification and analysis of cells
Patent #: 4125828
Issued on: 11/14/1978
Inventor: Resnick ,   et al.

Automated method and apparatus for classification of cells with application to the diagnosis of anemia
Patent #: 4199748
Issued on: 04/22/1980
Inventor: Bacus

Automated quantitative muscle biopsy analysis system
Patent #: 4210419
Issued on: 07/01/1980
Inventor: Castleman

Blood cell identification and classification system
Patent #: 4404683
Issued on: 09/13/1983
Inventor: Kobayashi ,   et al.

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Inventor

Assignee

Application

No. 06/730421 filed on 05/06/1985

US Classes:

702/19, Biological or biochemical348/26, Contour generator382/129DNA or RNA pattern reading

Examiners

Primary: Krass, Errol A.
Assistant: Dixon, Joseph L.

Attorney, Agent or Firm

International Class

G06K 9/00 (20060101)

Abstract

An operator-interactive automated chromosome analysis system is employed by an operator to locate and identify acceptable metaphase spreads, form a karyotype by rearranging the identified metaphase spreads in accordance with a predetermined arrangement of the twenty-three pairs of chromosomes naturally occurring in human beings, and display the karyotype on a display or a hardcopy printout, or both. The system comprises the following elements: a mechanized microscope system; a microscope and closed circuit television arrangement for microscopically scanning the chromosome spreads; a metaphase detector producing an output indicating metaphase detection; a television monitor for viewing the detected metaphase spreads; a photographic printer for producing a hardcopy representation of the detected metaphase spreads; and a computer, including a video interface, for controlling the mechanized microscope stage to locate the metaphase spreads, for analyzing the metaphase detector output to determine the location and grades of metaphases, for displaying a patient identifier on the monitor or hardcopy, and for rearranging and displaying the detected metaphase spreads so as to produce the karyotype.

Other References

  • Ledley et al., "Introduction to Chromosome Analysis", Comput. Biol. Med., vol. 2, pp. 107-128 (1972)
  • Lubs et al., "Automated Analysis of Differentially Stained Human Chromosomes" Nobel 23-Chromosome Identification (1973)
  • Golab, "MACDAC-An Inexpensive and Complete Biomedical Input and Output Display System", 23rd ACEMB, Wash. Hilton Hotel, Wash. D.C., Nov. 15-19, 1979
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