Magnetic resonance (MR) image enhancement compounds for specific areas of the brain

Patent 4656026 Issued on April 7, 1987. Estimated Expiration Date:

December 10, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3789832

Method of obtaining internal information of a measuring target from the out-side by the application of a nuclear magnetic resonance phenomenon
Patent #: 3932805
Issued on: 01/13/1976
Inventor: Abe , et al.

Phenethylamine antigenic conjugates, their preparation, antibodies, and use
Patent #: 4016146
Issued on: 04/05/1977
Inventor: Soares

Method of obtaining information of a specified or target area of a living body near its skin surface by the application of a nuclear magnetic resonance phenomenon
Patent #: 4240439
Issued on: 12/23/1980
Inventor: Abe , et al.

Imaging systems
Patent #: 4254778
Issued on: 03/10/1981
Inventor: Clow , et al.

Imaging systems
Patent #: 4315216
Issued on: 02/09/1982
Inventor: Clow , et al.

Nuclear magnetic resonance systems Patent #: 4449097
Issued on: 05/15/1984
Inventor: Young , et al.

Inventors

Application

No. 06/680058 filed on 12/10/1984

US Classes:

424/9.33, Nitroxide or nitroxide containing436/173, NUCLEAR MAGNETIC RESONANCE, ELECTRON SPIN RESONANCE OR OTHER SPIN EFFECTS OR MASS SPECTROMETRY436/803, STABE FREE RADICALS (E.G., SPIN IMMUNOASSAY, ETC.)436/806, ELECTRICAL PROPERTY OR MAGNETIC PROPERTY540/512, Chalcogen attached indirectly to nitrogen of the hetero ring by acyclic nonionic bonding540/514, Nitrogen in the 1-position substituent of the bicyclo ring system600/420Using detectable material placed in body

Examiners

Primary: Nucker, Christine M.
Assistant: Wieder, Stephen C.

Attorney, Agent or Firm

Zarley, McKee, Thomte, Voorhees & Sease

International Classes

A61K 49/20 (20060101)
A61K 49/06 (20060101)

Abstract

An improved imaging technique involving nuclear magnetic resonance. Known drug or neurotransmitter receptor ligands are covalently bound to magnetic resonance image enhancing spin label compounds, such as sterically hindered free radical nitroxide compounds, with the resulting adduct being administered to a patient, and thereafter when the ligand is bound to specific receptor sites in the soft tissue such as the brain, regional tissue area is assessed with nuclear magnetic resonance, allowing diagnostic discrimination.

Other References

Keana, J. F., Chemical Reviews, vol. 78, (1978), pp. 37-64
Brasch, Robert C., "Work in Progress: Nuclear Magnetic Resonance Study of a Paramagnetic Nitroxide Contrast Agent for Enhancement of Renal Structures in Experimental Animals", Radiology 147, 773 (1983)
Brasch, Robert C., "Brain Nuclear Magnetic Resonance Imaging Enhanced by a Paramagnetic Nitroxide Contrast Agent: Preliminary Report" AJR 141, 1019 (1983)
Brasch, Robert C., "Nuclear Magnetic Resonance Session" Investigative Radiology Jul.-Aug., 1984 (S148)