Transdermal drug delivery devices with amine-resistant silicone adhesives
Patent 4655767 Issued on April 7, 1987. Estimated Expiration Date: 
September 26, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 26, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2736721 2814601 2857356 3528940 3731683 3797494 3929704 Polyorganosiloxane pressure sensitive adhesives and articles therefrom Bandage for transdermally administering scopolamine to prevent nausea Ceramifiable silicone adhesives InventorsAssigneeApplicationNo. 06/780505 filed on 09/26/1985US Classes:424/448, Pressure sensitive adhesive means424/449, Transdermal or percutaneous428/156Including variation in thicknessExaminersPrimary: Lieberman, Allan M.Attorney, Agent or FirmInternational ClassA61K 9/70 (20060101)AbstractThis invention relates to an improved transdermal drug delivery device for the controlled transdermal delivery of amino-functional drugs. The improvement resides in providing the device with a silicone pressure-sensitive adhesive layer which has been chemically treated to reduce the silicon-bonded hydroxyl content of the pressure-sensitive adhesive composition to render the adhesive layer resistant to loss of tack and preserve the instant adherence of the device to the skin of a wearer during storage and while the device is being worn. Preferably, the composition used comprises a silicon-bonded hydroxyl radical containing resinous copolymer of R3 SiO1/2 units and SiO4/2 units and a polydiorganosiloxane which have been chemically treated with R3 SiO1/2 units where R is preferably a hydrocarbon radical such as a methyl group to reduce the silicon-bonded hydroxyl content of the adhesive and thereby its sensitivity to amino-functional drugs.Other References
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