Ophthalmic treatment by topical administration of cyclosporin

Patent 4649047 Issued on March 10, 1987. Estimated Expiration Date:

March 19, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventor

Kaswan, Renee

Assignee

University of Georgia Research Foundation, Inc.

Application

No. 06/713701 filed on 03/19/1985

US Classes:

514/11, Monocyclic514/772.2, Polyvinyl alcohol514/885, IMMUNE RESPONSE AFFECTING DRUG514/912, OPHTHALMIC514/914Inflammation

Examiners

Primary: Robinson, Douglas W.

Attorney, Agent or Firm

Oblon, Fisher, Spivak, McClelland, & Maier

International Classes

A61K 38/13 (20060101)
A61K 38/12 (20060101)
A61K 9/127 (20060101)
A61K 9/00 (20060101)

Abstract

The present invention relates to a method for the treatment of either phacoanaphylactic endophthalmitis or uveitis by administering at least one cyclosporin topically to the eyes. Topical application of cyclosporin provides cyclosporin to the anterior chamber, the posterior chamber and the vitreous body of the eye.

Other References

Chem. Abst. 102:214587v (1985)--Mosteller et al
Chem. Abst. 102:125267y (1985)--Williams et al
Chem. Abst. 102:89788h (1985)--Boisjolv et al
Chem. Abst. 101:103683h (1984)--Chan et al
Chem. Abst. 101:16979v (1984)--Mannis et al
Chem. Abst. 97 84951z (1982)--Nussenblatt et al
Chem. Abst. 97 439c (1982)--Kana et al
Chem. Abst. 94 185,629u (1981)--Nussenblatt et al
Amer. J. Ophthal. 96(3) 275-282 (1983)--Nussenblatt et al
Biosjoly et al., Prophylactic Topical Cyclosporine in Experimental Herpetic Stromal Keratitis, Arch Ophthalmol, 102, 1804, Dec. 1984
Mosteller et al., Penetration of Topical Cyclosporine into the Rabbit Cornea, Aqueous Humor, and Serum, Arch. Ophthalmol, 103, 101, Jan. 1985
Nussenblatt et al., Cyclosporin A Therapy in the Treatment of Intraocular Inflammatory Disease Resistant to Systemic Corticosteroids and Cytotoxic Agents, American Journal of Ophthalmology, 96, 275, Sep. 1983
Kaswan et al., Intraocular Penetration of Cyclosporin in Rabbits, ARVO Abstracts, Investigation Ophthalmol. Supp. 25, 3, p. 38, 1984