N-acyl peptide, processes for their preparation and pharmaceutical compositions thereof
Patent 4643990 Issued on February 17, 1987. Estimated Expiration Date: 
February 17, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 17, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3538070 3893992 Dipeptide narcotic antagonists Percompound activators Peptide, process for preparation thereof and use thereof N-Acylpeptide compound, processes for the preparation thereof and the pharmaceutical compositions Patent #: 4436726 InventorsAssigneeApplicationNo. 06/452827 filed on 12/23/1982US Classes:514/18, 3 or 4 peptide repeating units in known peptide chain514/19, 2 peptide repeating units in known peptide chain530/331, Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc.560/149, Sulfoxy in acid moiety560/169, Additional nitrogen in acid moiety560/170, Oxy, aldehyde or ketone group in acid moiety560/222, Phosphorus, sulfur or nitrogen in alcohol moiety560/251, Plural nitrogens in alcohol moiety560/252, Polyoxy alcohol moiety560/253Acyclic alcohol moietyExaminersPrimary: Phillips, Delbert R.Attorney, Agent or FirmInternational ClassesC07K 5/065 (20060101)C07K 5/00 (20060101) C07K 5/068 (20060101) C07K 5/072 (20060101) C07K 5/06 (20060101) A61K 38/00 (20060101) Foreign Application Priority Data1982-01-05 GBAbstractN-acylpeptides are disclosed of the formula: ##STR1## wherein R1 is alkanoyloxy or alkenoyloxy; R2 is alkyl or alkenyl; R3 and R4 are each lower alkyl, hydroxy(lower)alkyl, ar(lower)alkyl, esterified carboxy(lower)alkyl, carboxy(lower)alkyl, protected amino(lower)alkyl or amino(lower)alkyl; R5 is hydrogen, hydroxy(lower)alkyl, protected amino(lower)alkyl, amino(lower)alkyl, carboxy(lower)alkyl or esterified carboxy(lower)alkyl; R6 is carboxy, esterified carboxy or sulfo(lower)alkyl; A1, A2 and A3 are each bond or lower alkylene; and m and n are each an integer of 0 or 1; or its pharmaceutically acceptable salt. These compounds have anti-complementary activity and fibrinolytic activity, and are useful as therapeutic agents for immune-complex diseases or autoimmune diseases such as nephritis, rheumatic diseases, systemic lupus erythematosus, etc. and thrombosis such as cerebral apoplexy, coronary insufficiency, pulmonary embolism, etc.Other References
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