Novel cyclosporins
Patent 4639434 Issued on January 27, 1987. Estimated Expiration Date: 
March 19, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 19, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsAssigneeApplicationNo. 06/713429 filed on 03/19/1985US Classes:514/11, Monocyclic530/321, Containing only normal peptide links in the ring, i.e., homodetic cyclic peptides930/190, Antibiotic930/20, Containing modified or unusual amino acid (See note 1 and note 2)930/270Cyclic peptide or cyclic protein (See note 8)ExaminersPrimary: Phillips, Delbert R.Attorney, Agent or FirmInternational ClassesC07K 7/00 (20060101)C07K 7/64 (20060101) A61K 38/00 (20060101) Foreign Application Priority Data1984-03-23 GBAbstractCyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy--amino acid residue, typically of formula ##STR1## wherein X=-MeBmt- or -dihydro-MeBmt-, Y=-u-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R1 --CO--O--CH(R2)--CH(CO--)--NH--wherein R1 =H, C1-4 alkyl or phenyl and R2 =H or CH3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity. |
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