Spontaneous preparation of small unilamellar liposomes
Patent 4619794 Issued on October 28, 1986. Estimated Expiration Date: 
January 29, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 29, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod of preparing a controlled-release pharmaceutical preparation, and resulting composition Process for the preparation of liposomes in aqueous solution Immunoassay products and methods Liposome drug delivery systems Patent #: 4356167 InventorAssigneeApplicationNo. 06/696228 filed on 01/29/1985US Classes:264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)264/4.3, With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)424/450, Liposomes428/402.2, Microcapsule with fluid core (includes liposome)436/829LIPOSOMES (E.G., ENCAPSULATION, ETC.)ExaminersPrimary: Lovering, Richard D.Attorney, Agent or FirmInternational ClassA61K 9/127 (20060101)Foreign Application Priority Data1982-02-17 CHAbstractThe present invention relates to a novel advantageous process for the preparation of unilamellar liposomes in aqueous phase by converting a suitable lipid component, e.g. phosphatidic acid, into the ionic form by subjecting the lipid dispersion to a change in pH value and subsequently neutralizing it. Formation of the unilamellar liposomes is spontaneous, i.e. it takes place without additional external supply of energy. The liposomes obtainable by the process of this invention can be used therapeutically as carriers for drugs of the most widely different kind.Other References
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