N-homocysteine thiolactonyl retinamide and use thereof as an antineoplastic agent
Patent 4618685 Issued on October 21, 1986. Estimated Expiration Date: 
December 18, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 18, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesHomocysteine thiolactone perchlorate as a tumor promotor Homocysteine thiolactone salts and use thereof as anti-neoplastic agents Patent #: 4383994 InventorApplicationNo. 06/810175 filed on 12/18/1985US Classes:549/63Nitrogen attached directly to the hetero ring by nonionic bondingExaminersPrimary: Siegel, AlanAttorney, Agent or FirmInternational ClassesC07D 333/00 (20060101)C07D 333/36 (20060101) AbstractThis invention is concerned with a new compound, useful to reduce tumors in laboratory animals, having the following structural formula: ##STR1## The compound is prepared by reacting the free base of homocysteine thiolactone with all trans retinoic acid in the presence of dicyclohexylcarbodiimide as a dehydrating agent as follows: ##STR2## The reaction is carried out in a suitable non-polar solvent. The compound may also be used to agglutinize human blood platelets.Other References
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