Proteolytic, dry biopolymeric composition for treatment of wounds, and method of using same
Patent 4613502 Issued on September 23, 1986. Estimated Expiration Date: 
December 6, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 6, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2908614 2997423 3003917 3914413 Proteolytic enzymes as adjuncts to antibiotic prophylaxis of contaminated wounds Novel enzyme particles and their preparation Method of enzymatic debridement Patent #: 4361551 InventorsAssigneeApplicationNo. 06/679118 filed on 12/06/1984US Classes:424/94.3, Stabilized enzymes or enzymes complexed with nonenzyme (e.g., liposomes, etc.)424/499, Contains proteins or derivative or polysaccharides or derivative514/55, Chitin or derivative514/59Dextran or derivativeExaminersPrimary: Rosen, SamAttorney, Agent or FirmInternational ClassesA61K 38/43 (20060101)A61K 38/48 (20060101) C12N 11/00 (20060101) C12N 11/10 (20060101) A61L 26/00 (20060101) Foreign Application Priority Data1983-12-08 CSAbstractThe invention pertains to a cover of wounds in the form of a powder or a dry powdery fluid and is useful in covering and treating of ulcerous and necrotic wounds. It consists of animal or fungous chitin and chitosan in a powdered form of particle size 0.01 to 0.3 mm or of crosslinked dextran in the form of spheric particles of diameter 0.05 to 0.5 mm and of an immobilized protease. Enzymes are chemically bonded to the structure of the biopolymeric carrier and provide cleaning of the wound by dissolution of undesirable protein material, in particular fibrin, necrotic tissues, components of pus, and the like. In addition the adsorption and regeneration effects of powder act to provide suction of exudate and purulent matter infected with bacteria into interstitial capillary space. The cover according to the invention acts by fast cleaning of necrotic defects and speeds up the granulation and healing of the wound. The invention can be utilized in pharmaceutical production.Other References
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