Process for the preparation of N-(chloroaryl)-N',N'-dialkylamidines Patent #: 4169852
ApplicationNo. 05/932830 filed on 08/11/1978
US Classes:564/245N(prime)-aryl formimidines (i.e., benzene-N=CH-HNH, wherein substitution may be made for hydrogen, including those bonded directly to the benzene ring only)
ExaminersPrimary: Trousof, Natalie
Assistant: Hendriksen, L.
Attorney, Agent or Firm
International ClassA01N 37/52 (20060101)
AbstractA process for the production of N-(2-methyl-4-chlorophenyl)-formamidine derivatives of formula ##STR1## wherein R1 is hydrogen or an alkyl radical having 1 to 4 carbon atoms and R2 is an alkyl radical having 1 to 4 carbon atoms is disclosed which comprises reacting an N-substituted formamide with an inorganic acid chloride, such as phosphorus oxychloride, thionylchloride and phosgene, condensing the intermediate formed with o-toluidine and subsequently chlorinating the N-(2-methylphenyl)-formamidine derivative formed, all reaction steps involved in said process being carried out in the same solvent which is selected from the group of halogenated hydrocarbons.