U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Phenoxyethylamine derivatives

Patent 4609758 Issued on September 2, 1986. Estimated Expiration Date: Icon_subject May 9, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Aryloxyphenylpropylamines in treating depression Patent #: 4018895
Issued on: 04/19/1977
Inventor: Molloy ,   et al.

Inventor

Assignee

Application

No. 06/732478 filed on 05/09/1985

US Classes:

564/348, Hydroxy, bonded directly to carbon, or ether oxygen is attached directly or indirectly to the chain by acyclic nonionic bonding with no amino nitrogen between the hydroxy or attached ether oxygen and the aryl ring or ring system (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)560/142, Nitrogen or sulfur in phenolic moiety560/252, Polyoxy alcohol moiety564/171, Plural rings in substituent Q564/347The ether oxygen is bonded directly to the aryl ring or ring system

Examiners

Primary: Warren, Charles F.
Assistant: Sopp, John A.

Attorney, Agent or Firm

International Classes

C07C 233/00 (20060101)
C07C 233/12 (20060101)

Abstract

This invention provides a group of hydroxycycloalkanephenoxyethylamine antidepressant derivatives of the following structural formula: ##STR1## in which R1 is hydrogen or alkyl of 1 to 6 carbon atoms;R2 is alkyl of 1 to 6 carbon atoms;R3 and R4 are independently hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, halo or trifluoromethyl;R5 is hydrogen, alkyl of 1 to 6 carbon atoms or alkanoyl of 2 to 7 carbon atoms;and n is one of the integers 0, 1, 2 or 3;or a pharmaceutically acceptable salt thereof.

Other References

  • Sindelar et al., Coll. Czech. Chem. Commun., 46, 597 (1981)
  • Wong et al., J. Pharmacol. Exp. Ther., 222, 61-65 (1982)
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