New pharmaceutical forms for administration of medicaments by oral route, with programmed release
Patent 4609542 Issued on September 2, 1986. Estimated Expiration Date: July 1, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
The present invention relates to a new pharmaceutical form for oral use in the nature of delayed action and controlled absorption medicaments.This form comprises an association of miniaturized granules obtained by high to very high compression: (a) with pH control agents, (b) coated with excipients determining the slow penetration of digestive and/or (c) coated with a very thin layer of lipids. These miniaturized granules may contain glucose, nay have pH control agents with different solubilities, and may be in the form of miniaturized granules with a pH gradient.
Other References
Lachman et al, The Theory and Practice of Industrial Pharmacy 2nd Ed. (1976) Lea & Febiger, Phila., Pa., pp. 296-358, 439-465
Patel et al, J. Pharm. Sci. 64(5):869-872, May 1975, Oral Absorption Efficiency of Acid-Labile Antibiotics from Lipid-Drug Delivery Systems
Patel, S. P., Diss. Abstr. Int. B(1975) 35(8):4013-4014, The Use of Cholesterol, Cholesteryl Acetate and ଲ-Sitosterol as Specialized Lipid Carriers for Oral and Implantation Depot Therapy
Patel, S. P. et al, Drug Develop. Commun. 2(6):465-494 (1976), The Dissolution Rate and the Oral Absorption Efficiency of Selected Salicylates from Lipid-Drug Delivery Systems
Kim et al, J. Pharm. Sci. 66(11):1536-1540, Nov. 1977, Surface Tension Lowering and Dissolution Rate of Hydrocortisone from Solid Solutions of Selected N-Acyl Esters of Cholesterol
July 1, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
