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US Patent 4607039 - Quinoline derivatives which are 5-hydroxytryptamine antagonists
US Patent Issued on August 19, 1986
Estimated Patent Expiration Date:
August 19, 2003Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
August 19, 2003Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractCompounds of the formula: ##STR1## wherein A stands for the radical --(CH2)2 -- which may optionally be substituted by one or two (1-2C)alkyl radicals; Q stands for an oxygen or sulphur atom; R° stands for a (1-4C)alkyl, (1-4C)alkoxy or cyclopropyl radical; R1 stands for a defined (3-4C)alkyl radical, a phenyl radical which may optionally bear a defined substituent, or a defined heteroaryl radical of 5 or 6 ring atoms; and R2 and R3 stand for hydrogen or a (1-2C)alkyl radical; and pharmaceutically-acceptable acid-addition salts thereof. Processes for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are 5-hydroxytryptamine antagonists.Other References
| InventorsAssigneeApplicationNo. 06/488607 filed on 04/25/1983US Classes:514/312, Chalcogen attached directly to the six-membered hetero ring by nonionic bonding546/155, Plural chalcogens attached directly to the six-membered hetero ring by nonionic bonding546/157Chalcogen attached directly at 2-position by nonionic bondingField of Search546/155Plural chalcogens attached directly to the six-membered hetero ring by nonionic bondingExaminersPrimary: Daus, Donald G.Assistant: Rivers, Diana G. Attorney, Agent or FirmUS Patent ReferencesRe16394, 1572768, 1860286, 4035374, Imidazolyl alkylaminopyridone and pyridinethione compoundsIssued on: 07/12/1977 Inventor: Durant , et al.4235909, Octahydro-2H-pyrrolo[3,4-g]quinolines Issued on: 11/25/1980 Inventor: Bach , et al.4260764, 9-Hydroxyoctahydrobenzo [C] quinolines and intermediates therefor Issued on: 04/07/1981 Inventor: Johnson4343805, Heterocyclic compounds Issued on: 08/10/1982 Inventor: Crossley , et al.4426387, Piperid-4-yl ureas and thio ureas used as anti-depressant agents Issued on: 01/17/1984 Inventor: Archibald , et al.4435405Quinoline derivatives which are 5-hydroxytryptamine antagonists Issued on: 03/06/1984 Inventor: Blackburn , et al. International ClassesC07D 409/00 (20060101)C07D 409/04 (20060101) C07D 215/18 (20060101) C07D 215/36 (20060101) C07D 215/00 (20060101) C07D 215/22 (20060101) C07D 215/227 (20060101) C07D 333/00 (20060101) C07D 333/24 (20060101) Foreign Application Priority Data1982-05-04 GB |
