Compounds having antiinflammatory activity, obtained by complexation of piroxican with ଲ-cyclodextrin, and pharmaceutical compositions containing them
Patent 4603123 Issued on July 29, 1986. Estimated Expiration Date: 
November 13, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 13, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProtein obtained from cakes of vegetable origin Inclusion complexes of cyclodextrins and strong inorganic oxy-acids and process for their preparation Hormonal plant growth regulator Complex compounds Patent #: 4478995 InventorsAssigneeApplicationNo. 06/670979 filed on 11/13/1984US Classes:514/58, Dextrin or derivative536/103, Dextrin or derivative536/46Dextrin derivativesExaminersPrimary: Brown, Johnnie R.Assistant: Peselev, Elli Attorney, Agent or FirmInternational ClassesA61K 47/48 (20060101)C08B 37/00 (20060101) Foreign Application Priority Data1984-02-22 ITAbstractNew inclusion compounds of 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxyamide-1,1-dio xide with , ଲ or γ cyclodextrins, obtained by reaction of said cyclodextrins and said 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxyamide-1,1-dio xide in aqueous or water/organic solutions are described. The ratio between 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-1,1-dioxide and the cyclodextrins is comprised between 1:10 and 1:1; preferably, it is about 1:2.5.The compounds of the invention possess high antiinflammatory and analgesic activities, together with a considerably reduced gastrolesive action. |
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