Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
Patent 4596795 Issued on June 24, 1986. Estimated Expiration Date: 
April 25, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 25, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2827452 3420788 3453259 3459731 Water-soluble steroid compounds Patent #: 4383992 InventorAssigneeApplicationNo. 06/603839 filed on 04/25/1984US Classes:514/58, Dextrin or derivative536/103Dextrin or derivativeExaminersPrimary: Love, Ethel G.Attorney, Agent or FirmInternational ClassesA61K 47/48 (20060101)A61K 31/57 (20060101) A61K 31/565 (20060101) C08B 37/00 (20060101) AbstractThe administration of sex hormones, particularly testosteorne, progesterone and estradiol in the form of their complexes or inclusions with specific derivatives of cyclodextrins by the sublingual or buccal route results in effective transfer of these hormones into the systemic circulation, followed by only gradual elimination. To be effective in the above mode of administration, the derivatives of cyclodextrins must carry one or several substituents, each containing one or several hydroxy groups. Specially preferred are the following complexes: hydroxypropylbeta-cyclodextrin and poly-beta-cyclodextrin.Other References
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