Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids

Patent 4593073 Issued on June 3, 1986. Estimated Expiration Date:

April 23, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Synthetic resin-base, antibiotic compositions containing amino acids
Patent #: 4233287
Issued on: 11/11/1980
Inventor: Heusser , et al.

Protein adsorbent
Patent #: 4246351
Issued on: 01/20/1981
Inventor: Miyake , et al.

Pentapeptide modified resin
Patent #: 4258151
Issued on: 03/24/1981
Inventor: Goldstein , et al.

Pentapeptide modified resin Patent #: 4258152
Issued on: 03/24/1981
Inventor: Goldstein , et al.

Inventors

Assignee

The Royal Institution for the Advancement of Learing

Application

No. 06/726312 filed on 04/23/1985

US Classes:

424/78.01, DIGESTIVE SYSTEM REGULATOR CONTAINING SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI) (E.G., ANTI-DIARRHETIC, ANTICONSTIPATION, APPETITE SUPPRESSANT, LAXATIVE, ETC.):424/78.12, Adsorbate or treating agent contains nitrogen525/328.4, Monomer containing two or more nitrogen atoms, or two or more nitrogen containing monomers525/328.5, Polymer derived from sulfur monomer525/381, Three or more amine groups525/382, Two amine groups525/54.1, Containing chemically combined protein or biologically active polypeptide930/280Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Examiners

Primary: Michl, Paul R.

Attorney, Agent or Firm

Oblon, Fisher, Spivak, McClelland & Maier

International Classes

A61K 31/785 (20060101)
A61K 31/74 (20060101)
A61K 47/48 (20060101)
C08F 8/00 (20060101)
C08F 8/30 (20060101)
C07K 17/02 (20060101)
C07K 17/00 (20060101)
A61K 38/00 (20060101)

Abstract

The invention is concerned with a novel polymer addition product comprising hydrophilic polymer backbone having a molecular weight of at least about 5,000 and to which are attached amino acid containing pendants, the pendants containing at least one arginine or lysine amino acid. The polymeric compounds of the invention are highly efficient adsorbents for bilirubin and other bile pigments, as well as for bile acids such as cholic acid.