1,5-benzothiazepine derivatives and their pharmaceutical use
Patent 4590188 Issued on May 20, 1986. Estimated Expiration Date: 
February 4, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 4, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3075967 3309361 3341516 3562257 InventorsAssigneeApplicationNo. 06/698125 filed on 02/04/1985US Classes:514/211.07, Nitrogen attached directly or indirectly to the ring nitrogen of the seven-membered hetero ring by acyclic nonionic bonding (e.g., Diltiazem, etc.)540/488, Chalcogen in the hetero ring540/491The chalcogen and the nitrogen are in the 1,5-positions of the bicyclo ring system (e.g., 1,5-benzothiazepinone, etc.)ExaminersPrimary: Bond, Robert T.Attorney, Agent or FirmInternational ClassesC07D 281/00 (20060101)C07D 281/10 (20060101) Foreign Application Priority Data1984-02-18 GBAbstractNovel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein R1 is lower alkyl or lower alkoxy, R2 is hydrogen atom or lower alkanoyl, each one of R3 and R4 is lower alkyl, Ring A is a substituted benzene ring of the formula: ##STR2## Ra is lower alkyl, lower alkoxy, lower alkylthio or benzyloxy, each one of Rb and Rc is lower alkyl, lower alkoxy or halogen atom, and either one of Rd and Re is fluorine atom and the other one is hydrogen atom, or a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and its salt are useful as a hypotensive agent and/or a cerebral or coronary vasodilator. |
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