Method of treatment to inhibit metastasis
Patent 4588587 Issued on May 13, 1986. Estimated Expiration Date: 
May 13, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 13, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorAssigneeApplicationNo. 06/471197 filed on 03/01/1983US Classes:514/21, Produced by or extracted from animal tissue424/550Digestive system (e.g., salivary gland, etc.)ExaminersPrimary: Rosen, SamAttorney, Agent or FirmInternational ClassesC07K 14/81 (20060101)C07K 14/815 (20060101) A61K 38/00 (20060101) AbstractMethod for treating a patient to inhibit metastasis of malignant cells by administering to the patient a therapeutically effective amount of a composition including a blood anticoagulant and a protease inhibitor. A composition apparently unique for this purpose is a leech salivary gland extract, the anticoagulant effect and protease inhibitory effect of which are believed to be significant. Other significant components may also be present in the leech salivary gland extract and these components may act synergistically in producing the observed antimetastatic effect.Other References
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