Sulfonic resins having a therapeutical activity, preparation thereof and pharmaceutical compositions containing them
Patent 4587242 Issued on May 6, 1986. Estimated Expiration Date: 
March 7, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 7, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3562257 3646008 InventorsAssigneeApplicationNo. 06/709081 filed on 03/07/1985US Classes:424/78.13, Oxygen or sulfur heterocycle514/211.07, Nitrogen attached directly or indirectly to the ring nitrogen of the seven-membered hetero ring by acyclic nonionic bonding (e.g., Diltiazem, etc.)521/32, Treated with nitrogen-containing material540/491The chalcogen and the nitrogen are in the 1,5-positions of the bicyclo ring system (e.g., 1,5-benzothiazepinone, etc.)ExaminersPrimary: Bond, Robert T.International ClassesA61K 47/48 (20060101)A61K 31/55 (20060101) C07D 281/00 (20060101) C07D 281/10 (20060101) Foreign Application Priority Data1984-03-09 ITAbstractA pharmaceutical compound characterized by a delayed release of the therapeutically active component, comprising a sulfonic type ion exchange resin and cis(&#b1;)-3-acetyloxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyp henyl)-1,5-benzothiazepin-4(5H)one, or cis(&#b1;)-3-hydroxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphe nyl)-1,5-benzothiazepin-4(5H)one as a therapeutically active compound.A process for the preparation of the active compound.A pharmaceutical composition including said active compound, and use of said composition for the prophylaxis and therapy of acute and chronical coronary insufficiency and of arterial hypertension. |
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