Triazinones
Patent 4584298 Issued on April 22, 1986. Estimated Expiration Date: 
October 12, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 12, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesThiadizines 1,3,4-Thiadiazin-2-ones 1,2,4-Triazin-3(2H) ones 6-Aryl-1,2,4-triazin-6-ones which possess cardiotonic properties Patent #: 4503054 InventorsAssigneeApplicationNo. 06/660135 filed on 10/12/1984US Classes:514/242, Asymmetrical (e.g., 1,2,4-triazine, etc.)544/182Asymmetrical (e.g., 1, 2, 4-triazines, etc.)ExaminersPrimary: Ford, John M.Attorney, Agent or FirmInternational ClassesC07C 243/00 (20060101)C07C 243/38 (20060101) C07C 45/00 (20060101) C07D 295/21 (20060101) C07C 45/64 (20060101) C07D 253/00 (20060101) C07D 253/06 (20060101) C07D 273/00 (20060101) C07D 273/04 (20060101) C07D 285/16 (20060101) C07D 285/00 (20060101) C07D 295/00 (20060101) Foreign Application Priority Data1981-11-12 GBAbstractHeterocyclic compounds of the formula ##STR1## wherein either X is --CR1 R2 and Y is --O--, --S-- or --NR3 --, wherein R1, R2 and R3, which may be the same or different, each is hydrogen or alkyl of up to 4 carbon atoms;or X is --O--, --S-- or --NH-- and Y is --CR1 R2 -- wherein R1 and R2 have the meanings stated above;wherein either R4 is hydrogen, fluoro or chloro, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atoms, and R5, R6 and R7, which may be the same or different, each is hydrogen, fluoro, chloro, bromo or iodo, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atoms, provided that R4, R5, R6 and R7 are not all hydrogen;or R4 is bromo and R5, R6 and R7 have the meanings stated above, provided that R5, R6 and R7 are not all hydrogen;or R4 and R5 together, or R5 and R6 together, or R4 and R7 together, form the --CH=CH--CH=CH-- group and the other two of R4, R5, R6 and R7 have the meanings stated above; processes for their manufacture and pharmaceutical compositions containing them. The compounds possess cardiotonic and/or antihypertensive activity.Other References
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