U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Analgesic compositions

Patent 4582835 Issued on April 15, 1986. Estimated Expiration Date: Icon_subject December 5, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Assignee

Application

No. 06/678478 filed on 12/05/1984

US Classes:

514/282, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)514/812Narcotic

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Class

A61K 31/485 (20060101)

Foreign Application Priority Data

1983-12-06 GB

Abstract

A method of treating pain which comprises the administration to a patient of a parenterally or sublingually effective dose of buprenorphine together with an amount of naloxone sufficient to prevent substitution in an opiate dependent subject. Preferably when the administration is parenteral the weights of naloxone and buprenorphine are within the ratio of 1:3 to 1:1 and when administered sublingually the weights are within the ratio of 1:2 to 2:1.

Other References

  • Chem. Abst. 94-150268y (1984)
  • Chemical Abstracts 90, 145726j
  • Manara et al., Dev. Neurosci, (Amsterdam) 1978, 4 (Charact. Funct. Opioids) 225-6
  • Dettmar et al., Biochem. Soc. Trans. 1978, 6(5), 1004-6 (=Chem. Abs. 90, 197597n (1979)
  • Ramabadran et al., Endog. Exog. Opiate Agonists Antagonists, Proc. Int. Narc. Res. Club. Conf. 1979 (Pub 1980) 471-4 (-Chem. Abs. 94, 15027u (1981))
  • Rance et al., Endog. Exog. Opiate Angonists Antagonists, Proc. Int. Narc. Res. Club. Conf. 1979 (Pub 1980) 387-90 (-Chem. Abs., 94, 150268y (1981))
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