Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor

Patent 4582831 Issued on April 15, 1986. Estimated Expiration Date:

November 16, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3591584

Crystalline benzothiazine dioxide salts Patent #: 4434164
Issued on: 02/28/1984
Inventor: Lombardino

Inventor

Robertson, Robert L.

Application

No. 06/672028 filed on 11/16/1984

US Classes:

514/226.5, One of the cyclos is a 1,2-thiazine (e.g.,1,2-benzothiazines, etc.)544/49Benzothiazines (including hydrogenated)

Examiners

Primary: Jiles, Henry R.
Assistant: Mullins, J. G.

Attorney, Agent or Firm

International Classes

F16L 57/00 (20060101)
C07D 417/00 (20060101)
C07D 417/12 (20060101)

Abstract

A novel crystalline form of the monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide has been prepared. This novel crystalline form is designated as polymorph I and is useful in therapy as a non-steroidal anti-arthritic agent. Methods for preparing this polymorph from readily available materials are provided.

Other References

J G. Lombardino et al., "Potent Antiinflammatory N-Heterocyclic 3-Carboxamides of 4-Hydroxy-2-Methyl-2H-1,-2H-1,2-2-Benzothiazine 1,1-Dioxide", Journal of Medicinal Chemistry, vol. 16, No. 5, p. 493, (1973)