Monoclonal antibodies specific for human hematopoietic cell surface glycoproteins
April 15, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod of producing tumor antibodies Method of producing antibodies Process for producing antibodies to hepatitis virus and cell lines therefor Complement-fixing monoclonal antibody to human T cells, and methods of preparing same Monoclonal antibody to human T cells, and methods for preparing same Monoclonal antibody to a human thymocyte antigen and methods of preparing same Monoclonal antibody to a human prothymocyte antigen and methods of preparing same Monoclonal antibody to a human monocyte antigen and methods of preparing same Monoclonal antibody to a human T cell antigen and methods of preparing same Patent #: 4364937 InventorApplicationNo. 06/470586 filed on 02/28/1983US Classes:530/388.7, Binds hematopoietic cell or component or product thereof (e.g., erythrocyte granulocyte, macrophage, monocyte, platelet, myelogenous leukemia cell, bone marrow stem cell, granulocytic cell-surface antigen, hemoglobin, thrombospondin, glycophorin, etc.)435/41, MICRO-ORGANISM, TISSUE CELL CULTURE OR ENZYME USING PROCESS TO SYNTHESIZE A DESIRED CHEMICAL COMPOUND OR COMPOSITION435/70.21, Producing monoclonal antibody530/388.73, Binds lymphocytic or lymphocytic-like cell or component or product thereof (e.g., B cell, B-lineage bone marrow cell, null cell, natural killer cell, B-lymphoblastoid cell, B-lineage acute lymphoblastic leukemia cell, B-lymphocytic cell-surface antigen, etc.)530/388.75Binds T-lymphocytic cell or component or product thereof (e.g., T cell, thymocyte, T-lineage bone marrow cell, T-lymphoblastoid cell, T-lineage acute lymphoblastic leukemia cell, T-lymphocytic cell-surface antigen, etc.)ExaminersPrimary: Marantz, SidneyAttorney, Agent or FirmInternational ClassesC07K 16/28 (20060101)C07K 16/18 (20060101) AbstractMonoclonal antibodies are produced for a family of glycoproteins which are selectively expressed on the surface of nucleated human hematopoietic cells but which are absent from other normal human cells. Mice are inoculated with human hematopoietic cells or fragments thereof, and spleen cells obtained from the mice are fused with murine myeloma cells to produce hybridomas. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificity for surface glycoproteins of nucleated human hematopoietic cells. Antibodies can be obtained from the culture growth medium or from ascitic fluid of mice bearing the hybridoma tumor and can be used to distinguish lymphomas from carcinomas.Other References
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