Quinoline derivatives
Patent 4576953 Issued on March 18, 1986. Estimated Expiration Date: 
February 23, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 23, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 1572768 Quinoline derivatives which are 5-hydroxytryptamine antagonists Patent #: 4435405 InventorAssigneeApplicationNo. 06/583035 filed on 02/23/1984US Classes:514/312, Chalcogen attached directly to the six-membered hetero ring by nonionic bonding546/157Chalcogen attached directly at 2-position by nonionic bondingExaminersPrimary: Daus, Donald G.Assistant: Benson, Robert Attorney, Agent or FirmInternational ClassesC07D 215/36 (20060101)C07D 215/00 (20060101) C07D 215/227 (20060101) Foreign Application Priority Data1983-03-29 GBAbstractCompounds of the formula: ##STR1## wherein X stands for an oxygen or sulphur atom, n stands for 1 or 2, R1 stands for a defined (3-4C)alkyl radical, a cyclopropyl radical, or a phenyl radical which may optionally bear a halogeno, (1-4C)alkyl or (1-4C)alkoxy substituent, and R2 stands for hydrogen or a (1-4C)alkyl radical, and pharmaceutically-acceptable acid-addition salts thereof. Process for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are peripherally selective 5-HT antagonists.Other References
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