Method for preparing N6,8-disubstituted 3',5'-cyclic adenosine monophosphate and salt thereof
Patent 4567254 Issued on January 28, 1986. Estimated Expiration Date: 
September 19, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 19, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3856776 6,8-Disubstituted purine derivatives of 9-ଲ-D-ribofuranosyl 3',5'-cyclic phosphate Process for producing N6,O2' -diacyladenosine-3',5'-cyclic phosphoric ester alkali metal salts Patent #: 4458067 InventorsAssigneeApplicationNo. 06/652093 filed on 09/19/1984US Classes:536/26.13Adenine or substituted adenineExaminersPrimary: Love, Ethel G.Attorney, Agent or FirmInternational ClassesC07H 19/20 (20060101)C07H 19/00 (20060101) AbstractA method for preparing an N6,8-disubstituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR1## wherein X denotes a halogen atom or ##STR2## N3, OH or OR, R being an alkyl or aralkyl group; A⊕ denotes a hydrogen ion, alkali metal ion, ammonium ion or organic ammonium ion; and R1 denotes an alkyl or aromatic group, which method comprises reacting an 8-substituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula (II) ##STR3## wherein X and A61 are as defined above, with an aldehyde represented by the general formulawherein R1 is as defined above, to form an imine compound represented by the general formula ##STR4## wherein X, R1 and A⊕ are as defined above, as an intermediate, and then reducing the imine compound.Other References
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