U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Rate-controlled drug release system

Patent 4559054 Issued on December 17, 1985. Estimated Expiration Date: Icon_subject August 9, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Novel drug delivery device
Patent #: 3948254
Issued on: 04/06/1976
Inventor: Zaffaroni

Microporous drug delivery device
Patent #: 3993072
Issued on: 11/23/1976
Inventor: Zaffaroni

Vaginal contraceptive system made from block copolymer
Patent #: 4215691
Issued on: 08/05/1980
Inventor: Wong

Delivery means for biologically active agents
Patent #: 4235988
Issued on: 11/25/1980
Inventor: Fildes ,   et al.

Biocompatible material comprising a base polymer bulk graft polymerized with an ethylenically unsaturated carboxylic acid Patent #: 4377010
Issued on: 03/22/1983
Inventor: Fydelor ,   et al.

Inventor

Assignee

Application

No. 06/639277 filed on 08/09/1984

US Classes:

424/424, Membrane or diffusion barrier424/434, Mucosal (e.g., nasal, etc.)424/449, Transdermal or percutaneous424/473, With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)424/486Synthetic polymer

Examiners

Primary: Metz, Andrew H.
Assistant: Chapman, Terryence

Attorney, Agent or Firm

International Classes

A61K 9/28 (20060101)
A61M 31/00 (20060101)

Abstract

A drug release device employing a block copolymer of poly(ether-urethane)/poly(dimethyl siloxane) is useful for dispensing lipophilic drugs at a high controlled rate for prolonged periods of time. The initial "burst effect" of drug release experienced with prior drug release devices is eliminated or at least substantially reduced with these devices.

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