Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
Patent 4556676 Issued on December 3, 1985. Estimated Expiration Date: 
December 3, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 3, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3704323 Aminophenyltetralin compounds Patent #: 4045488 InventorsApplicationNo. 06/184447 filed on 09/05/1980US Classes:514/554, Amine addition salt of the acid514/555, Benzene ring in acid moiety514/647, Amino nitrogen and a ring bonded directly to the same ring and any other amino nitrogen in the compound is bonded directly to one of the rings558/426, Benzene ring attached indirectly to the cyano group by nonionic bonding (i.e., alicyclic ring between the benzene ring and the cyano group)560/101, Plural rings bonded directly to the same carbon in acid moiety560/57, Plural rings bonded directly to the same acyclic carbon in acid moiety562/468, Plural rings bonded directly to the same carbon562/491, Plural rings bonded directly to the same carbon562/598, Unsaturated564/272, Benzylidene imines (i.e., Q-benzene-CH=NH, wherein Q is a substituent or hydrogen and substitution may be made for hydrogen only)564/304, Of benzene ring containing compounds564/308, Polycyclo ring system568/326Polycyclo ring systemExaminersPrimary: Hines, Robert V.Attorney, Agent or FirmInternational ClassesC07C 49/755 (20060101)C07C 49/697 (20060101) C07C 49/00 (20060101) C07C 43/21 (20060101) C07C 43/00 (20060101) C07C 45/00 (20060101) C07C 45/46 (20060101) C07C 57/00 (20060101) C07C 57/60 (20060101) C07C 57/58 (20060101) AbstractNovel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalen amine and its pharmaceutically acceptable acid addition salts.Other References
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