Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production

Patent 4554351 Issued on November 19, 1985. Estimated Expiration Date:

May 5, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Dihydrocyclosporin C
Patent #: 4108985
Issued on: 08/22/1978
Inventor: Ruegger , et al.

Organic compounds
Patent #: 4117118
Issued on: 09/26/1978
Inventor: Harri , et al.

Organic compounds
Patent #: 4210581
Issued on: 07/01/1980
Inventor: Ruegger , et al.

Organic compounds
Patent #: 4220641
Issued on: 09/02/1980
Inventor: Traber , et al.

Cyclosporin derivatives, their production and pharmaceutical compositions containing them
Patent #: 4288431
Issued on: 09/08/1981
Inventor: Traber , et al.

Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production Patent #: 4396542
Issued on: 08/02/1983
Inventor: Wenger

Inventor

Wenger, Roland

Assignee

Sandoz Ltd.

Application

No. 06/491991 filed on 05/05/1983

US Classes:

544/177, Ether containing546/216, Chalcogen bonded directly to ring carbon of the piperidine ring546/219, Plural chalcogens bonded directly to ring carbons of the piperidine ring560/163, Aromatic alcohol moiety560/170, Oxy, aldehyde or ketone group in acid moiety562/567, Oxy, aldehyde, or ketone930/190, Antibiotic930/20, Containing modified or unusual amino acid (See note 1 and note 2)930/21, Containing D-amino acid930/270Cyclic peptide or cyclic protein (See note 8)

Examiners

Primary: Phillips, Delbert R.
Assistant: Moezie, F. T.

Attorney, Agent or Firm

International Classes

C07C 47/263 (20060101)
C07C 29/00 (20060101)
C07C 47/277 (20060101)
C07C 47/20 (20060101)
C07C 29/10 (20060101)
C07D 303/22 (20060101)
C07C 43/178 (20060101)
C07C 43/00 (20060101)
C07C 45/00 (20060101)
C07C 45/29 (20060101)
C07C 45/67 (20060101)
C07D 303/00 (20060101)
C07C 45/30 (20060101)
C07D 263/20 (20060101)
C07D 263/00 (20060101)
C07D 317/00 (20060101)
C07D 317/26 (20060101)
C07D 317/12 (20060101)
C07D 317/30 (20060101)
C07K 7/64 (20060101)
C07K 7/00 (20060101)
C07D 317/20 (20060101)
C07D 317/22 (20060101)
C07K 5/00 (20060101)
C07K 5/06 (20060101)

Foreign Application Priority Data

1980-02-14 CH

Abstract

A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.