Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
Patent 4554101 Issued on November 19, 1985. Estimated Expiration Date: 
January 28, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 28, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDetection of cancer associated polypeptide antigen and preparation of antibodies thereto Method for concentration and purification of antigens and antibodies Method of producing antibodies Conjugate of streptococcal M protein peptide vaccine Synthetic vaccine peptide epitomes of hepatitis B surface antigen Patent #: 4415491 InventorApplicationNo. 06/461802 filed on 01/28/1983US Classes:530/324, 25 or more amino acid residues in defined sequence424/185.1, Amino acid sequence disclosed in whole or in part; or conjugate, complex, or fusion protein or fusion polypeptide including the same424/186.1, Disclosed amino acid sequence derived from virus424/187.1, Retroviridae (e.g., feline leukemia, etc.)424/189.1, Hepatitis virus424/190.1, Disclosed amino acid sequence derived from bacterium (e.g., Mycoplasma, Anaplasma, etc.)424/191.1, Disclosed amino acid sequence derived from parasitic organism (e.g., Dirofilaria, Eimeria, Trichinella, etc.)424/198.1, Hormone or other secreted growth regulatory factor, differentiation factor, intercellular mediator, neurotransmitter, or fragment thereof424/204.1, Virus or component thereof424/207.1, Retroviridae (e.g., feline leukemia virus, bovine leukemia virus, avian leukosis virus, equine infectious anemia virus, Rous sarcoma virus, HTLV-I, etc.)424/210.1, Subunit vaccine containing hemagglutinin or neuraminidase424/216.1, Calciviridae or picornaviridae, except hepatitis A virus (e.g., foot-and- mouth disease virus (FMDV), coxsackievirus, echovirus, avian encephalomyelitis virus, Mengovirus, etc.)424/218.1, Togaviridae or Flaviviridae, except hepatitis C virus (e.g., yellow fever virus, bovine viral diarrhea virus, dengue virus, equine viral arteritis virus, equine encephalitis virus, Japanese B encephalitis virus, Sindbis virus, flavivirus, etc.)424/233.1, Adenoviridae, adeno-like virus, or Parvoviridae (e.g., adenovirus, canine parvovirus, mink enteritis virus, hemorrhagic enteritis virus, feline panleukopenia virus, egg drop syndrome virus, etc.)424/244.1, Streptococcus (e.g., Group B Streptococcus, pneumococcus or Streptococcus pneumoniae, etc.)424/245.1, Corynebacterium (e.g., Corynebacterium diphtheriae, etc.)424/257.1, Escherichia (e.g., Escherichia coli, etc.)424/261.1, Vibrio (e.g., Vibrio cholera, etc.)424/269.1, Parasitic protozoan (e.g., Trypanosoma, Trichomonas, Leishmania, Entamoeba, etc.)424/276.1, Characterized by molecular weight436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN514/12, 25 or more peptide repeating units in known peptide chain structure514/13, 16 to 24 peptide repeating units in known peptide chain514/14, 12 to 15 peptide repeating units in known peptide chain514/15, 9 to 11 peptide repeating units in known peptide chain514/16, 7 or 8 peptide repeating units in known peptide chain514/17, 5 or 6 peptide repeating units in known peptide chain514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI530/325, 24 amino acid residues in defined sequence530/326, 15 to 23 amino acid residues in defined sequence530/327, 11 to 14 amino acid residues in defined sequence530/328, 8 to 10 amino acid residues in defined sequence530/329, 6 to 7 amino acid residues in defined sequence530/389.1, Polyclonal antibody or immunogloblin of identified binding specificity530/389.4, Binds virus or component or product thereof (e.g., virus-associated antigen, etc.)530/389.5, Binds bacterium or similar microorganism or component or product thereof (e.g., Pseudomonas, Chlamydia, Clostridium, bacterium-associated antigen, etc.)530/806, ANTIGENIC PEPTIDES OR PROTEINS530/868, INVOLVING AUTOIMMUNITY, ALLERGY, IMMEDIATE HYPERSENSITIVITY, DELAYED HYPERSENSITIVITY, IMMUNOSUPPRESSION, OR IMMUNOTOLERANCE930/10, PEPTIDE OR PROTEIN SEQUENCE930/110, Gonadotropin; related peptides930/20, Containing modified or unusual amino acid (See note 1 and note 2)930/200, Bacterial peptide or bacterial protein (See note 6)930/220, Viral peptide or viral protein (See note 6)930/221, Retrovirus related, or human immunodeficiency virus related, or simian immunodeficiency virus related930/222, Foot and mouth disease related930/223, Hepatitis related930/230Multicellular plant peptide or multicellular plant proteinExaminersPrimary: Wiseman, Thomas G.Assistant: Teskin, Robin L. Attorney, Agent or FirmInternational ClassesA61K 39/39 (20060101)C07K 14/02 (20060101) C07K 14/005 (20060101) AbstractAn immunoglobulin is provided which consists essentially of a mono-specific, hetero-molecular antibody which is mono-specific to a single antigenic or allergenic determinant. The antibody is specific to the H-epitope of a protein antigen or allergen. The H-epitope is defined by a sequence of at least six amino acids corresponding to the sequence of such amino acids in the protein antigen or allergen where the greatest local average hydrophilicity of the protein antigen or allergen is found.Other References
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