U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor

Patent 4553974 Issued on November 19, 1985. Estimated Expiration Date: Icon_subject August 14, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3562820

Method of treatment of calcium disorders using phosphonoalkane-polycarboxylic acids
Patent #: 3962433
Issued on: 06/08/1976
Inventor: Worms ,   et al.

Preparing natural tissue for implantation so as to provide improved flexibility
Patent #: 3966401
Issued on: 06/29/1976
Inventor: Hancock ,   et al.

Non-antigenic, non-thrombogenic infection-resistant grafts from umbilical cord vessels and process for preparing and using same
Patent #: 3988782
Issued on: 11/02/1976
Inventor: Dardik ,   et al.

Substitute blood vessel and a process for preparing the same
Patent #: 4098571
Issued on: 07/04/1978
Inventor: Miyata ,   et al.

Transplants
Patent #: 4120649
Issued on: 10/17/1978
Inventor: Schechter

Method for inhibiting mineralization of natural tissue during implantation
Patent #: 4323358
Issued on: 04/06/1982
Inventor: Lentz ,   et al.

Coating for bioprosthetic device and method of making same
Patent #: 4378224
Issued on: 03/29/1983
Inventor: Nimni ,   et al.

Method for inhibiting mineralization of natural tissue during implantation Patent #: 4402697
Issued on: 09/06/1983
Inventor: Pollock ,   et al.

Inventor

Assignee

Application

No. 06/640725 filed on 08/14/1984

US Classes:

8/94.11, Internal tissues623/1.42, Drug delivery623/1.47, Collagen8/94.18With organic material

Examiners

Primary: Clingman, A. Lionel

Attorney, Agent or Firm

International Classes

A61L 27/00 (20060101)
A61L 27/36 (20060101)

Abstract

A process for the treatment of collagenous tissue to adapt it for use in a prosthetic implant and to promote the growth of endothelial cells thereon after implantation comprising treatment with at least one surfactant prior to fixation, treatment with agents which inhibit calcification and agents which resist attack by phagocytic cells and optional treatment with stabilizing agents.

Other References

  • M Potokar, et al., Atherosclerosis, 30 (1978), 313-320
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