Gonadoliberin derivatives process for the preparation and pharmaceutical compositions thereof

Patent 4552864 Issued on November 12, 1985. Estimated Expiration Date:

May 4, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3888836

Peptides having LH-RH/FSH-RH activity
Patent #: 4024248
Issued on: 05/17/1977
Inventor: Konig , et al.

Peptides affecting gonadal function
Patent #: 4382922
Issued on: 05/10/1983
Inventor: Rivier , et al.

GnRH Agonists Patent #: 4410514
Issued on: 10/18/1983
Inventor: Vale, Jr. , et al.

Inventors

Assignee

Reanal Finomvegyszergyar

Application

No. 06/608261 filed on 05/04/1984

US Classes:

514/15, 9 to 11 peptide repeating units in known peptide chain514/800, LHRH LIKE530/328, 8 to 10 amino acid residues in defined sequence530/339, Segment condensation, e.g., Ugi condensation, etc.930/130, Luteinizing hormone-releasing hormone (LH-RH); related peptides930/20, Containing modified or unusual amino acid (See note 1 and note 2)930/21, Containing D-amino acid930/23Containing halogen (See note 3)

Examiners

Primary: Phillips, Delbert R.

Attorney, Agent or Firm

International Classes

C07K 7/00 (20060101)
C07K 7/23 (20060101)
A61K 38/00 (20060101)

Foreign Application Priority Data

1982-05-25 HU

Abstract

The invention relates to new gonadoliberin derivatives of the formula (I)whereinY represents a glycine-amide group or an -NH-alkyl group having 1 to 4 carbon atoms in the alkyl moiety,X stands for a D-thyroxyl, D-thyronyl or D-4-chlorophenylalanyl group,and acid addition salts and metal complexes thereof.The new nona- and decapeptide derivatives have an excellent luteinizing and folliculus stimulating hormone releasing activity, and they can therefore be used as active ingredients in pharmaceutical compositions for human or veterinary application.