Patent ReferencesFollicular phase estrogen or progestin with physiologic estrogen/progestin luteal phase replacement drug delivery system Multi-phase combination-type sequential preparation for oral contraception and method of oral contraception Patent #: 4378356 InventorAssigneeApplicationNo. 06/607038 filed on 05/04/1984US Classes:514/170, Plural Compounds containing cyclopentanohydrophenanthrene ring systems514/177, Oxygen double bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/182Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring systemExaminersPrimary: Roberts, Elbert L.Attorney, Agent or FirmInternational ClassA61K 31/565 (20060101)AbstractA method of contraception in which an estrogen and a progestogen are administered daily in a three phase sequence for 21 days is disclosed. In the first phase a combination of an estrogen and a progestogen in a low but contraceptively effective daily dosage corresponding in estrogenic activity to 0.02-0.05 mg of 17-ethinylestradiol and in progestogenic activity to 0.065-0.75 mg of norethindrone is administered for 5-8 days; followed by the administering of the same dosage of estrogen and a progestogen corresponding in progestogenic activity to 0.25-1.0 mg of norethindrone for 7-11 days; followed by the administering of the same dosage of estrogen and a progestogen corresponding in progestogenic activity to 0.35-2.0 mg of norethindrone for 3-7 days; followed by 6-8 days without administering either an estrogen or a progestogen. | |