Sustained release therapeutic compositions
Method and composition for the preparation of controlled long-acting pharmaceuticals
Pharmaceutical formulation for slow release via controlled surface erosion
Therapeutic compositions with enhanced bioavailability
Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose Patent #: 4389393
ApplicationNo. 06/596095 filed on 04/02/1984
US Classes:424/480, Cellulose or derivative514/781, Cellulose or derivative514/964SUSTAINED OR DIFFERENTIAL RELEASE TYPE
ExaminersPrimary: Rose, Shep K.
Attorney, Agent or Firm
International ClassA61K 9/20 (20060101)
AbstractA carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a controlled and prolonged release pattern upon administration, the carrier base material being a mixture of one or more nonionic cellulose ethers and an anionic surfactant, and wherein at least one of the cellulose ethers is a modified hydroxypropylmethylcellulose having a number average molecular weight of less than 50,000 and has been modified by successive or concurrent exposure to moisture and air.