Lyophilized cyclophosphamide
Patent 4537883 Issued on August 27, 1985. Estimated Expiration Date: 
March 13, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 13, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3018302 3732340 InventorsAssigneeApplicationNo. 06/589202 filed on 03/13/1984US Classes:514/110, Phosphorus is part of a ring514/960SIGNIFICANT, TABLET FORMULATION (E.G., DESIGNATED EXCIPIENT, DISINTEGRANT, GLYDENT OR LUBRICANT, ETC.)ExaminersPrimary: Meyers, Albert T.Assistant: Morrison, Joyce L. Attorney, Agent or FirmInternational ClassesA61K 31/675 (20060101)A61K 9/19 (20060101) A61K 47/26 (20060101) AbstractA lyophilized pharmaceutical solid composition containing cyclophosphamide for reconstitution with water to provide a solution for oral or parenteral administration. This lyophilized cyclophosphamide solid composition demonstrates improved stability, solubility characteristics and enhanced appearance compared with currently available dry powder pre-mix compositions of cyclophosphamide. The lyophilized solid composition contains about 20 parts by weight of cyclophosphamide, about 11/4-2 parts by weight of water and from about 10-85 parts by weight of excipient which is comprised mainly of mannitol. Processes for making the composition are disclosed.Other References
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