Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
Patent 4536518 Issued on August 20, 1985. Estimated Expiration Date: 
August 20, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 20, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2887509 3704323 Aminophenyltetralin compounds Patent #: 4029731 InventorsApplicationNo. 06/090240 filed on 11/01/1979US Classes:514/647, Amino nitrogen and a ring bonded directly to the same ring and any other amino nitrogen in the compound is bonded directly to one of the rings514/555, Benzene ring in acid moiety564/308Polycyclo ring systemExaminersPrimary: Hines, Robert V.Attorney, Agent or FirmInternational ClassesC07C 49/697 (20060101)C07C 49/00 (20060101) C07C 43/21 (20060101) C07C 43/00 (20060101) C07C 45/00 (20060101) C07C 45/46 (20060101) C07C 57/00 (20060101) C07C 45/28 (20060101) C07C 57/60 (20060101) C07C 57/58 (20060101) AbstractNovel cis-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of serotonin (5-hydroxy-tryptamine), thereby alleviating serotonin abnormalities at central receptor sites. The preferred embodiment is the enantiomer cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenam ine and its pharmaceutically acceptable acid addition salts.Other References
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