Detection of lung cancer using breath luminescence

Patent 4534360 Issued on August 13, 1985. Estimated Expiration Date:

May 27, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

1395948

2060325

3888630

Inventor

Williams, Martin D.

Application

No. 06/498762 filed on 05/27/1983

US Classes:

600/473, Infrared radiation128/206.29, Including means inserted in mouth600/543Breath collection

Examiners

Primary: Coven, Edward M.

Attorney, Agent or Firm

Howson and Howson

International Classes

A61B 5/08 (20060101)
G01N 33/483 (20060101)
G01N 33/497 (20060101)

Abstract

Subjects may be screened for possible lung cancer by a breath luminescence measurement apparatus and technique. The apparatus comprises a photon counter with special provisions for the exclusion of light from sources other than the patient's breath. A special light exclusion mask is used together with tortuous breath exhaust passages to exclude external light. A gauze plug in the breathing tube excludes light emitted by the patient's mouth tissues. Special adapters are provided so that the photon counter can be used for endoscopic measurement of internal tissue luminescence and for sample luminescence measurements.

Other References

Doiron et al., "Fluorescence Bronchoscopy . . . ", Chest 76:1, Jul. 1979, pp. 27-32
Kinesy et al., "Endoscopic System . . . ", Rev. Sci. Instrum., Oct. 1980, pp. 1403-1406
Balchum, O. J., Doiron, D. R., Profio, A. E., and Huth, G. C., (1982)--Fluorescence Bronchoscopy for Localizing Early Bronchial Cancer & Carcinoma in situ, in Recent Results in Cancer Research, vol. 82, pp. 97-120, P. R. Bond, ed., Springer Verlag, Berlin, Heidelberg, and New York
De Chatelet, L. R. and Shirley, P. S., (1981), Evaluation of Chronic Granulomatous Disease by a Chemiluminescence Assay of Microliter Quantities of Whole Blood, Clinical Chemistry, 27, 1739-1941
Krotozynski, B., Gabriel G., and O'Neill, H., Claudio, M. P. A., (1977), Characterization of Human Expired Air: A Promising Investigative and Diagnostic Technique, Journal of Chromatographic Science, 15, 239-244
Williams, M. D., Leigh, Jr., J. S. & Chance, B., Hydrogen Peroxide in Human Breath and its Probable Role in Spontaneous Breath Luminescence, Annals New York Academy of Sciences (May 28, 1982), pp. 478-483
Williams, M. D., Chance, B. and Leigh, Jr., J. S., Spontaneous Ultraviolet Chemiluminescence of Human Breath in situ, VII Int. Biophysics Congress and II Pan-American Biochemistry Congress Program and Abstracts, Mexico City, MX, p. 104 (Sep. 1981)
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Williams, M. D. and Chance, B., Optical Spectrum, Decay Time, Temporal Distribution and Correlation with Peroxide of Human Breath Spontaneous Chemiluminescence, Biophysics Journal (1983)
Williams, M. D. and Chance B., Spontaneous Chemiluminescence of Human Breath, Spectrum, Lifetime, Temporal Distribution, and Correlation with Peroxide, The Journal of Biological Chemistry (Mar. 25, 1983), pp. 3628-3631
Williams, Letter, Science (Feb. 12, 1982), vol. 215, No. 4534, p. 745
Williams, M. D., Breath-Lung Luminescence, The Gerontologist 22,1/1 (Abstract No. 141) (Nov. 1982)