Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions
April 4, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 1834015 2944058 3846445 Bis-basic ethers of carbazole 9-Substituted 3-aminocarbazole compounds 1,2,3,4-Tetrahydro-carbazole compounds and ଲ-adrenergic compositions N-substituted 1-amino-3-phenoxy-propan-2-ol compounds and therapeutic compositions containing them Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases Amide derivatives Alkanolamine derivatives InventorsAssigneeApplicationNo. 06/479921 filed on 04/04/1983US Classes:514/411, Tricyclo ring system having the five-membered hetero ring as one of the cyclos514/339, Ring nitrogen in the polycyclo ring system546/276.7, Polycyclo ring system having the five-membered hetero ring as one of the cyclos548/444Chalcogen or nitrogen attached indirectly to the tricyclo ring system by acyclic nonionic bondingExaminersPrimary: Brust, Joseph PaulAttorney, Agent or FirmInternational ClassesC07D 209/00 (20060101)C07D 209/88 (20060101) C07D 317/64 (20060101) C07D 317/00 (20060101) Foreign Application Priority Data1978-04-13 DEAbstractCarbazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R1 is hydrogen, lower alkanoyl or aroyl;R2 is hydrogen, lower alkyl or arylalkyl;R3 is hydrogen or lower alkyl;R4 is hydrogen or lower alkyl, or when X is oxygen, R4 together with R5 can represent --CH2 --O--;X is a valency bond, --CH2 --, oxygen or sulfur;Ar is mono- or bicyclic aryl or pyridyl;R5 and R6 are individually selected from hydrogen, halogen, hydroxyl, lower alkyl, aminocarbonyl, lower alkoxy, aralkyloxy, lower alkylthio, lower alkylsulphinyl or lower alkylsulphonyl;R5 and R6 together can represent methylenedioxy;and the salts thereof with physiologically acceptable acids are outstandingly effective in the treatment and prophylaxis of circulatory and cardiac diseases, e.g., hypertension and angina pectoris.Other References
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