Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof
Patent 4501726 Issued on February 26, 1985. Estimated Expiration Date: 
July 8, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 8, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesIntravascularly-administrable, magnetically-localizable biodegradable carrier Magnetically-localizable, biodegradable lipid microspheres Method of delivering a therapeutic agent to a target capillary bed Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres Patent #: 4357259 InventorsApplicationNo. 06/522159 filed on 07/08/1983US Classes:424/1.37, Radionuclide or intended radionuclide in an organic compound424/490, Coated (e.g., microcapsules)424/493, Containing polysaccharides (e.g., sugars)428/403, Coated600/12, Magnetic element placed within body (e.g., injected, inserted, implanted, etc.)977/706, Carbohydrate977/773, Nanoparticle (structure having three dimensions of 100 nm or less)977/776, Ceramic powder or flake977/778, Within specified host or matrix material (e.g., nanocomposite films, etc.)977/838, Magnetic property of nanomaterial977/915Therapeutic or pharmaceutical compositionExaminersPrimary: Padgett, Ben R.Assistant: Wallen, T. J. Attorney, Agent or FirmInternational ClassesA61K 9/50 (20060101)A61K 9/51 (20060101) Foreign Application Priority Data1981-11-12 SEAbstractAn intravascularly administrable, magnetically responsive nanosphere or nanoparticle made up of a crystalline carbohydrate matrix, preferably starch, enclosing a magnetic material, is described. The nanosphere or nanoparticle is produced by dissolving a carbohydrate together with a magnetic material to form a solution which is emulsified in a hydrophobic solvent from which the carbohydrate is crystallized.The resulting magnetic nanospheres having an average diameter not exceeding 1500 nm are capable of transporting pharmacologically active substances and can be injected intravenously for subsequent concentration in a part of the body by means of a magnetic field.Other References
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