U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Pharmaceutical sustained-release compositions

Patent 4499066 Issued on February 12, 1985. Estimated Expiration Date: Icon_subject July 30, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Re27107

2987445

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3115441

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Inventors

Application

No. 06/403475 filed on 07/30/1982

US Classes:

424/465With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Class

A61K 9/20 (20060101)

Foreign Application Priority Data

1981-08-05 IT

Abstract

New pharmaceutical sustained-release compositions, formulated as tablets, are prepared by mixing the active ingredient with excipient already granulated and coated with polymers and/or copolymers or a polymers- and/or copolymers-mixture substantially insoluble in water. Such pharmaceutical preparations enable one to enhance or to decrease very easily and precisely the sustained-release effect by regulating the granulometry of the excipient, the excipient/active ingredient ratio, the hardness, and the percentage of the polymers and/or copolymers or of the polymers- and/or copolymers-mixture.

Other References

  • Ritschel, W. A., Drug Design, vol. IV, Chapter 2, edited by Ariens (Academic Press, N.Y. 1973)
  • Ballard, B. E., Nelson, E., Chapter 89 in "Remington's Pharmaceutical Sciences", 14th Edition, Mack Publishing Co., Philadelphia 1970
  • Baker, R. W., Chapter 2 in "Controlled Release of Biologically Active Agents", edited by Tanquary and Lacey (Plenum Press, N.Y. 1974)
  • Dakkuri, A., Butler, L. D. and De Luca, P. P., J. Pharm. Sci., 67, 357 (1978)
  • Itoh, M., Nakano, M., Juni, K. and Sekikawa, H., Chem. Pharm. Bull., 28, 1051 (1980)
  • Samuelov, Y., Donbrow, M. and Friedman, M., J. Pharm. Sci., 68, 325 (1979)
  • Buri, P. and Doelker, E., Pharm. Acta Helv., 55, 189 (1980)
  • Gurny, R., Guitard, P., Buri, P. and Sucker, H., Pharm. Acta Helv., 52, 182 (1977)
  • Zentner, G. M., Cardinal, J. R. and Sung Wan Kim, J. Pharm. Sci., 67, 1352 (1978)
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