Plasminogen activator derivatives
Patent 4495285 Issued on January 22, 1985. Estimated Expiration Date: 
October 27, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 27, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesNon-immunogenic polypeptides Heat-resistant water soluble urokinase derivative Patent #: 4349630 InventorsApplicationNo. 06/437009 filed on 10/27/1982US Classes:435/215, Urokinase435/181, Attached to the carrier via a bridging agent435/212Acting on peptide bond (e.g., thromboplastin, leucine amino-peptidase, etc., (3.4))ExaminersPrimary: Shapiro, Lionel M.International ClassesA61K 47/48 (20060101)A61K 47/48 (20060101) C12N 9/96 (20060101) C12N 9/96 (20060101) C12N 9/72 (20060101) C12N 9/72 (20060101) A61K 38/00 (20060101) A61K 38/00 (20060101) Foreign Application Priority Data1981-10-30 JPAbstractA derivative of a human-originated non-immunogenic plasminogen activator is disclosed which comprises at least one polyalkylene glycol attached with at least one coupling agent to amino acid side chains of said plasminogen activator, said polyalkylene glycol having a molecular weight of 200-20,000 and optionally containing one or more alkyl and/or alkanoyl groups as substituents. Also disclosed are a process for producing such derivative and a thrombolytic agent containing such derivative.Other References
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