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Anhydrous composition, stable to oxidation, based on anthralin or one of its derivatives, in a carrier consisting of a fatty acid alkyl ester and a thickener, and its use in the treatment of skin diseases

Patent 4495203 Issued on January 22, 1985. Estimated Expiration Date: Icon_subject October 22, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Dithranol compositions for topical applications
Patent #: 4203969
Issued on: 05/20/1980
Inventor: Yarrow ,   et al.

Dithranol compositions stabilized with alpha hydroxyacids
Patent #: 4287214
Issued on: 09/01/1981
Inventor: Van Scott ,   et al.

Anti-acne composition
Patent #: 4299826
Issued on: 11/10/1981
Inventor: Luedders

Therapeutic compositions and vehicles for topical pharmaceuticals
Patent #: 4316902
Issued on: 02/23/1982
Inventor: Yu ,   et al.

Stable dithranol compositions in anhydrous vehicles Patent #: 4367224
Issued on: 01/04/1983
Inventor: Van Scott ,   et al.

Inventors

Application

No. 06/435983 filed on 10/22/1982

US Classes:

514/732, Polycyclo ring system (e.g., naphthols, etc.)514/863Psoriasis

Examiners

Primary: Schenkman, Leonard

Attorney, Agent or Firm

International Classes

A61K 47/20 (20060101)
A61K 47/14 (20060101)

Foreign Application Priority Data

1981-10-23 FR

Abstract

Anhydrous composition, stable to oxidation, of anthralin or a derivative thereof.This composition contains anthralin or a derivative thereof in a carrier composed of (i) at least one fatty acid alkyl ester, the fatty acid having 12 to 18 carbon atoms and the alkyl radical having 2 or 3 carbon atoms, and (ii) at least one thickener taken from the group made up of silicas having particle sizes less than 30 mμ and polyethylene powders having densities between 0.9 and 0.96 (g/cm3).This composition is used in the treatment of skin diseases, particularly psoriasis.

Other References

  • Remington's Pharmaceutical Sciences, 16th Ed., 1980, p. 356
  • Chemical Abstracts 76:144782y (1972)
  • Cosmetics, Science & Technology (Balsam et al.), 2nd Ed., vol. 1, pp. 194-195, (1972)
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