Process for preparing solid unit dosage forms of ultra-low dose drugs
Patent 4489026 Issued on December 18, 1984. Estimated Expiration Date: 
September 7, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 7, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3196827 3836618 3843393 InventorAssigneeApplicationNo. 06/415294 filed on 09/07/1982US Classes:264/123, Autogenously or by activation of dry coated particles424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)427/2.18En masse rotating means employed (e.g., rotating pan, tumbling)ExaminersPrimary: Silverberg, SamAttorney, Agent or FirmInternational ClassA61K 9/16 (20060101)AbstractA process for the preparation of solid unit dosage forms is disclosed wherein a fine spray of a dilute solution of a pharmaceutically active material is gradually finely sprayed over an extended time period onto fine excipient particles undergoing agitation. Extremely small amounts of the pharmaceutically active material are deposited on the excipient particles, allowing the resulting powder to be formed into solid unit dosage forms, such as tablets, containing 100 mcg or less of the active ingredient per unit, with high content uniformity among the solid unit dosage forms. | |
