Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
October 4, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3804776 Method of preparing a controlled release liquid pharmaceutical composition Immunological preparations Large unilamellar vesicles (LUV) and method of preparing same Process for the preparation of liposomes Compositions containing aqueous dispersions of lipid spheres Process for the preparation of liposomes in aqueous solution Method of encapsulating biologically active materials in lipid vesicles Immunoassay products and methods Patent #: 4342826 InventorsAssigneeApplicationNo. 06/432686 filed on 10/04/1982US Classes:264/4.6, Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.)424/1.21, Molecular bilayer structure (e.g., vesicle, liposome)424/450, Liposomes428/402.2, Microcapsule with fluid core (includes liposome)436/829, LIPOSOMES (E.G., ENCAPSULATION, ETC.)514/171, With additional active ingredient514/951, POWDERS, GRANULES OR PARTICLES OF SPECIFIED MESH OR PARTICLE SIZE514/962CAPSULE (E.G., GELATIN, ETC.)ExaminersPrimary: Lovering, Richard D.Attorney, Agent or FirmInternational ClassA61K 9/127 (20060101)AbstractThis invention provides an improved procedure for producing large multilamellar lipid vesicles (MLV), which may be used to encapsulate a biologically active material, particularly lipophilic substances. According to this invention, a lipid film is formed on inert, solid contact masses within a vessel, by evaporating an organic solvent therefrom. Subsequent agitation in the presence of an aqueous liquid, followed by a period in which the vessel remains undisturbed yields the multilamellar vesicles. The procedure permits the encapsulation of both hydrophilic and lipophilic materials.Other References
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