Synthetic phosphatidyl cholines useful in forming liposomes
Patent 4485045 Issued on November 27, 1984. Estimated Expiration Date: 
May 26, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 26, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References Re30748 2002885 2531275 2689863 Phospholipid derivative with an antilipemic and antiarteriosclerotic effect Method of emulsifying cholesterol, cholesterol esters and triglyceride compounds Patent #: 4320121 InventorAssigneeApplicationNo. 06/382296 filed on 05/26/1982US Classes:554/80, Nitrogen containing (e.g., cephalins, lecithins, etc.)264/4.3, With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)264/4.6, Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.)264/4.7, Solid-walled microcapsule formed by in situ polymerization424/450, Liposomes428/402.2, Microcapsule with fluid core (includes liposome)428/402.22, Addition polymer from unsaturated monomers only428/516, Monoolefin polymer560/185, Acylated oxy in acid moiety987/233Alchohol moiety of ester contains at least three hydroxyl functions or derivatives thereof and wherein the oxygen atoms of the derivative can be attributed to the hydroxyl functions; e.g., phosphatides, lecithin, etc. (9/10)ExaminersPrimary: Lovering, Richard D.Attorney, Agent or FirmInternational ClassesA61K 9/127 (20060101)C07F 9/00 (20060101) C08F 30/00 (20060101) C08F 30/02 (20060101) C07F 9/10 (20060101) AbstractLower-ω-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the ω-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene. |
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