Reactor system and method for polynucleotide synthesis
Patent 4483964 Issued on November 20, 1984. Estimated Expiration Date: 
June 20, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 20, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesChemical synthesis apparatus for preparation of polynucleotides Patent #: 4353989 InventorsAssigneeApplicationNo. 06/506153 filed on 06/20/1983US Classes:536/25.5, Homopolymers having repeating sequences of four or more identical nucleotide units422/116, Sensed condition is operating time and control is operation sequencer422/131, Organic polymerization435/317.1, MISCELLANEOUS (E.G., SUBCELLULAR PARTS OF MICRO-ORGANISMS, ETC.)435/320.1, VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.)435/820, SUBCELLULAR PARTS OF MICRO-ORGANISMS525/54.1, Containing chemically combined protein or biologically active polypeptide525/54.11, Solid polymer treated by stepwise reaction with naturally occurring alpha or beta amino acid or a material which contains a residue of said amino acid, e.g., a functionally protected amino acid, etc.525/54.23Previously formed solid polymer is derived from ethylenically unsaturated reactants onlyExaminersPrimary: Kight, JohnAssistant: Nutter, Nathan M. Attorney, Agent or FirmInternational ClassesB01J 19/00 (20060101)C07H 21/00 (20060101) AbstractA reactor system and method for synthesizing or degrading polynucleotides and other linear polymers includes a tubular reactor connected to a reagent manifold. The polynucleotide is immobilized on a loosely packed solid-phase support material in the tubular reactor, and reagents are sequentially introduced into the tubular reactor. After each reagent is introduced, the tubular reactor is isolated from the reagent manifold and the reagent agitated by alternately pressurizing the opposite ends of the tubular reactor. The method provides rapid and efficient synthesis of polynucleotides. |
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